I want to request testing by your laboratory, what do I have to do for this?

You will need to contact your doctor. Please tell your doctor to visit our website and to download our test kit order form (USA or outside USA), fill and sign it and submit it to our office together with a copy of his/her medical license. After that we will send a test kit to your doctor’s office.

I am a doctor and it is the first time I am going to send you samples. Should I send you my medical license?

Yes, please submit a copy of your medical license to our office by fax or e-mail.

The instruction sheet for Nagalase says to stop immune stimulants prior to testing. However, these are part of the treatment for the patient. Will these immune stimulants affect the result if they are not stopped for testing?

The immune stimulants decrease the Nagalase activity. We advise to draw blood for the Nagalase test just before the immune stimulant medication is given. If this medication is given once a week, as is mostly the case, then this will pose no problem. However, if a one week interval is not possible: at least try to use the same time period each time to have the best follow up.

The instruction sheet for the Methylation Pathway Panel says to stop medication (if possible) prior to testing. What kind of medication should be discontinued and for what time?

It would be better to stop intake of vitamin B6 and B12 for 48 hours before the blood draw since the high intake of these vitamins may affect the results.

Histamine in Blood

Histamine is a chemical messenger that mediates a wide range of cellular responses, including allergic an inflammatory reactions, gastric acid secretion and possibly neurotransmission in parts of the brain. Histamine is a poweful vasodilator. It is formed of histidine and secreted by mast cells as a result of allergic reactions or trauma.

Three main biotypes had been identified among schizophrenic patients around the histamine axis with biochemical abnormalities which are also seen among the population at large:

– Patients with low blood histamine (histapenia; about 50%): these paranoid and hallucinatory patients are low in serum folate and high in creatine phosphokinase (CPK), serum copper and ceruloplasm The patients sensitive to wheat gluten represent a special group of the histapenic patients.

– The high histamine group (histadelia; about 20%) has suicidal depression tendency. The blood histamine is contained in the basophils, so they frequently have high basophil counts. Their serum copper is low or normal.

– The persons with pyroluria (30-40%) are normal in histamine and normal in trace elements except for those who are low in serum zinc. The mauve factor in their urine depletes them of zinc and pyridoxine (B6). Their insight and affect are usually better than of other schizophrenic types

Low histamine and high histamine are not necessarily pathological conditions but help define the three main biotypes outlined above, which may be associated with conditions amenable to dietary or other treatment.

TEST INDICATIONS

– Allergy

– Paranoia and hallucination

– Suicidal depression

– Schizophrenia

– Stress

– Lyme disease and hyper/hypo-methylation

COMPLEMENTARY TESTS

– Methylation pathway panel

– Kryptopyrrol (Mauve factor) in urine

– Vitamins in blood

– Elements/toxical elements in blood

– Amino acids in urine (esp methionine and histidine).

– Food allergy IgE/IgG4 panel

Methodology

Histamine in whole blood is measured directly by utilizing high sensitivity and high specificity LC/MSMS methodology. This methodology was validated against Dr. Karl Pfeiffer’s method for total whole blood histamine determination.

Material required

1mL of whole blood (EDTA tube)Ordering information

Please contact our office, [email protected]