FIGLU

FIGLU (formiminoglutamic acid) is a compound that can be measured in laboratory tests to assess the functional status of folic acid (vitamin B9) within the body. It’s used as a marker to detect potential folic acid deficiency or disorders related to folic acid metabolism. Here’s how FIGLU and folic acid are related:

• Folic Acid (Vitamin B9):

  Folic acid, also known as vitamin B9, is an essential water-soluble vitamin that plays a crucial role in various cellular processes, including DNA synthesis, cell division, and the metabolism of certain amino acids.

• Folic Acid Deficiency:

  Folic acid deficiency can result from inadequate dietary intake, impaired absorption, certain medical conditions, or medications that interfere with its absorption. Folic acid deficiency can lead to anemia (megaloblastic anemia), which is characterized by large, immature red blood cells and a reduced ability of the bone marrow to produce normal blood cells.

• FIGLU Test:

  The FIGLU test is used to assess the body’s ability to metabolize histidine, an essential amino acid. Histidine normally undergoes a conversion process that requires folic acid. If folic acid levels are insufficient, histidine metabolism may be disrupted, leading to the accumulation of FIGLU in the urine.

• Clinical Significance:

  The FIGLU test is primarily used as a diagnostic tool to identify folic acid deficiency or disorders that affect folic acid metabolism. It helps healthcare professionals determine the underlying cause of megaloblastic anemia or other related symptoms.