I want to request testing by your laboratory, what do I have to do for this?

You will need to contact your doctor. Please tell your doctor to visit our website and to download our test kit order form (USA or outside USA), fill and sign it and submit it to our office together with a copy of his/her medical license. After that we will send a test kit to your doctor’s office.

I am a doctor and it is the first time I am going to send you samples. Should I send you my medical license?

Yes, please submit a copy of your medical license to our office by fax or e-mail.

The instruction sheet for Nagalase says to stop immune stimulants prior to testing. However, these are part of the treatment for the patient. Will these immune stimulants affect the result if they are not stopped for testing?

The immune stimulants decrease the Nagalase activity. We advise to draw blood for the Nagalase test just before the immune stimulant medication is given. If this medication is given once a week, as is mostly the case, then this will pose no problem. However, if a one week interval is not possible: at least try to use the same time period each time to have the best follow up.

The instruction sheet for the Methylation Pathway Panel says to stop medication (if possible) prior to testing. What kind of medication should be discontinued and for what time?

It would be better to stop intake of vitamin B6 and B12 for 48 hours before the blood draw since the high intake of these vitamins may affect the results.

Choline – Health Diagnostics and Research Institute

Choline

Choline is an essential nutrient that plays a significant role in the body’s methylation pathway, which is a complex biochemical process involved in various essential functions, including gene expression, protein synthesis, detoxification, and more. Choline contributes to methylation as a methyl donor, providing a methyl group (CH3) that is used in a variety of reactions. Some key facts about choline:

Methyl Donor:

Choline is metabolized in the body to produce a molecule called betaine, also known as trimethylglycine. Betaine serves as a methyl donor, providing a methyl group to other molecules and compounds as part of methylation reactions.
Methionine Synthesis:

One important role of choline-derived betaine is its involvement in the remethylation of homocysteine to form methionine. Methionine is an essential amino acid that serves as the precursor for S-adenosylmethionine (SAM), a key methyl donor in numerous methylation reactions.
Cell Membrane Structure:

Choline is a component of phospholipids, which are major constituents of cell membranes. It helps maintain the structural integrity and fluidity of cell membranes.
Neurotransmitter Synthesis:

Choline is a precursor for the synthesis of the neurotransmitter acetylcholine. Acetylcholine is involved in nerve signaling and muscle contraction and plays a role in cognitive function and memory.
Methyl Donor:

Choline also functions as a methyl donor in various biochemical reactions. Methylation is a chemical process that is important for gene expression, metabolism, and overall cellular function.
Liver Health:

Choline is involved in the metabolism of fats and cholesterol. Adequate choline intake is important for preventing the accumulation of fat in the liver, which can lead to non-alcoholic fatty liver disease.
Brain Development:

Choline is particularly important during pregnancy and infancy for proper brain development. Adequate choline intake during pregnancy is associated with better cognitive outcomes in children.
Deficiency:

Choline deficiency can lead to various health issues, including impaired fat metabolism, liver dysfunction, and potential cognitive and memory problems.

Choline

Choline

Methyl Donor:

Methionine Synthesis:

Cell Membrane Structure:

Neurotransmitter Synthesis:

Methyl Donor:

Liver Health:

Brain Development:

Deficiency: